Unbiased estimation for response adaptive clinical trials
نویسندگان
چکیده
منابع مشابه
Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility
Seamless phase II/III clinical trials combine traditional phases II and III into a single trial that is conducted in two stages, with stage 1 used to answer phase II objectives such as treatment selection and stage 2 used for the confirmatory analysis, which is a phase III objective. Although seamless phase II/III clinical trials are efficient because the confirmatory analysis includes phase II...
متن کاملResponse-Adaptive Repeated Measurement Designs for Clinical Trials
In a response-adaptive design (RAD), we review and update the trial on the basis of outcomes in order to achieve a specific goal. Optimal designs for clinical trials are usually constructed under a single objective. In this paper, we develop a new adaptive allocation rule to improve the current strategies of building response adaptive designs to construct multiple-objective designs. The purpose...
متن کاملAdaptive Design for Clinical Trials
Adaptive design is a trial design that allows modifications to some aspects of the trial after its initiation without undermining the validity and integrity of the trial. Adaptive design makes it possible to discover and rectify inappropriate assumptions in trial designs, lower development costs and reduce the time to market. It has become very attractive to the pharmaceutical industries. In th...
متن کاملFeasibility Estimation for Clinical Trials
At least 90% of trials are extended by at least 6 weeks because investigators fail to enroll patients on schedule (Ledford, 2011). It is therefore important at trial design-time to have good insight in how the choice of the eligibility criteria affects the recruitment rate. Based on that insight, trial designers can then adjust the eligibility criteria in order to ensure realistic recruiting ra...
متن کامل. e ON UNBIASED ESTIMATION FOR RANDOMIZED RESPONSE MODELS
For quantitative randomized response models, optimal unbiased estimation of regular functionals of distribution functions is considered. In this context, distribution theory of Hoeffding's U-statistics and von Mises' differentiable statistical functions is extended to randomized response models. Estimation of the basic distributions is also considered.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistical Methods in Medical Research
سال: 2015
ISSN: 0962-2802,1477-0334
DOI: 10.1177/0962280215597716